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drbio45

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drbio45

Re: donotknowityet post# 41627

Tuesday, 02/06/2007 7:14:08 PM

Tuesday, February 06, 2007 7:14:08 PM

Post# of 252819
Why did it happened? These were large double blind trials with low p values. Why is that (and that is not only Alexion) that you frequently have great double blind phase II and phase II results followed by a bomb in the pivotal trial?
Anybody has any good explanation?


Everyone says how wonderful alexion trial was. They had an 18 percent reduction of events with a p value of .08 in a 3 or 4 thousand patient trial

mcu had a 37 percent reduction with a p value of .028 in a 300 patient arm

is everyone nutz
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