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Re: sstyles post# 373876

Sunday, 03/27/2022 10:38:44 AM

Sunday, March 27, 2022 10:38:44 AM

Post# of 447245
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843090/
Yes I think MITIGATE is large enough and because of Omicron ...definitely enough events ....for stat sig data .
JMO
Posters Iryo and Pdude have also looked into this trial so U might ask their opinions also
note

A total enrollment of 16,500 patients pre-randomized in a 1 (IPE):10 (usual care) allocation ratio with an overall event rate of 15 per 100 person-years, would result in 80% power to detect a RR=0.82 (ie, 18% relative rate reduction, 2.7% absolute rate reduction) given a 2-sided ( P value less then I think ..typo ) 0.05.


They have increased the enrollment numbers in at least the passive arm
Kiwi
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