Amarin Corp Plc (AMRN)

[Whalatane]

Pdude. in response to some of your comments

U dont trust Kaiser because all their controls should be on Vascepa ?

R-IT results are based on patients with LDL below 100 mg/dl on optimal statin therapy with TG's still over 150 mg/dl . Do U know how many in the MITIGATE control fit this profile ? ...or are even on optimal statin therapy ...or even if their LDL is below 100 mg/dl but TG's are still over 150 mg /dl ?
We dont know if the lipid profile in MITIGATE is anywhere close to the lipid profile of those in R-IT .

How many contracted Covid ?
Omicron ravaged the MITIGATE recruiting areas of Nth Ca. At one pt 1 in every 4 tests came back positive for Covid .
MITIGATE is the best trial we are likely to see to determine if Vascepa reduces the hospitalization rate or urgent care visits for Covid .
1 in 4 is a very high covid positivity rate and the profile of those in the trial ( unlike the PREPARE-IT trials ) are those we know with high rates of hospitalization ...ie elderly with comorbities .
Most in MITIGATE will be over 70 , prior event ( stented , stroke etc ) and many are likely to be diabetic and have high blood pressure .
This is a high risk population

P values ... read the design and rational of MITIGATE linked previously

Interim only ... They discuss in the video I linked why they would probably not run an interim. MITIGATE is complete . They will present Top Line data as a Late Breaker at ACC on April 3rd
At least thats my understanding so correct if necessary

Kiwi