NorthWest Biotherapeutics Inc (NWBO)

[skitahoe]

HL,

Is it possible that DCVax-Prostate, Brain, Lung, etc. are all actually the same product, made from the Lysate of the cancer and in fact all can be defined by DCVax-L.

DCVax-Direct is different as it doesn't require the lysate from the tumor, it's injected into the tumor directly and creates the vaccine from within.

I know currently the intent is to use Direct on inoperable tumors, and that's the way the trials should be run. If in fact its benefits are seen in that venue, I question if it's use prior to surgery on operable tumors shouldn't be considered. As I see it, the biggest benefit of such treatment would be getting vaccine into the mets before the tumor is removed. It's the unseen and inoperable mets that later create new tumors. While creating DCVax-L from the tumor will certainly be of benefit, I would hope the benefit could be even greater if DCVax-Direct were injected some period of time before the tumor was surgically removed.

I could certainly be wrong about this if the presents of DCVax-Direct within the tumor detracted in some way from the Lysate used to create the DCVax-L. I welcome the thoughts of others on this matter.

Gary