NorthWest Biotherapeutics Inc (NWBO)

[MI Dendream]

Block randomization or some enhanced version of this has been a standard in large scale regulated clinical research for literally decades. This is done to ensure that randomization is as close to balanced as possible.

To have an imbalance of 32 patients and the events that transpired post August 2015 halt can only be explained this way. If you have another possible explanation, I am all ears as I have been every single time I have thrown these theories out over the past 4 years. No one can come up with a plausible explanation. Ex and other have tried and were blown to smithereens. Maybe you don’t call this fact,,, I suppose that could be considered by some a judgement call. To me, the verdict has been delivered.

I know you can find the 2017 JTM article yourself.

And as a reminder, to force an imbalance in this way dramatically reduces the power of the study. 331 patients randomized 2:1 is more powerful than 2.34:1. Meaning the power to detect a difference between two groups statistically.