Wednesday, December 22, 2021 3:51:30 PM
But your analysis of the science supporting the Anavex molecules has been right-on, from the start. It’s this. Simply, over the years lots of info on the Anavex molecules treating various (mostly CNS diseases) in both murines (lab rodents) and humans has appeared. Anyone with any curiosity would ask some questions about these results; particularly with any knowledge, scientific (me) or general (you), about new drugs in general.
Yes, you, too, looked for side effects information, and questionable therapeutic outcomes (such as those of the other Alzheimer’s drug, Aduhelm). You searched and considered the information on Anavex 2-73, and you didn’t find much (well, anything) that was negative.
Actually, a few years ago, there were two things negative about the science of blarcamesine. First, it simply hadn’t yet been tested for any length or size in real humans. Clinical tests in humans were preliminary, tiny, and even uncontrolled (no placebo arms). Therefore, the early accounts of efficacy were legitimately suspect. Big trials were needed; today, they are ongoing and will come to conclusion shortly.
The other really big question was how blarcamesine, as a single small molecule might be able to prompt such a wide diversity of efficacious results; AND, do it so safely. Simply, there was no biochemical explanation. The molecular specifics of the drug’s mechanisms of action (MOAs) were a mystery. Especially when working in the CNS. You don’t have to have scientific training to know that drugs acting in the CNS almost universally have considerable side effects. Blarcamesine had virtually none.
But, now, there have been larger human trials. Not a one has produced either therapeutic failures, or negating adverse events. Simply, every strand of evidence shows that the drug works, safely.
Finally, it is now more fully understood how this happens, what the biochemical mechanisms of action of the drug are: propitious activation of the sigma-1 receptor protein, which consequently modulates and promotes a diversity of favorable downstream cell-keeping processes, resulting in cell health (for a diversity of diseases).
All of us will continue to search for negating results and evidence that would poke sinking holes in the ever more detailed Anavex science story. You were correct. You found none at the beginning, and no such evidence of inefficacy or safety hazard has appeared. Well done.
Recent AVXL News
- Anavex Life Sciences to Present at the H.C. Wainwright 26th Annual Global Investment Conference 2024 • GlobeNewswire Inc. • 09/03/2024 11:30:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/06/2024 09:21:05 PM
- Anavex Life Sciences Reports Fiscal 2024 Third Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 08/06/2024 11:30:00 AM
- Anavex Life Sciences to Announce Fiscal 2024 Third Quarter Financial Results on Tuesday, August 6, 2024 • GlobeNewswire Inc. • 08/01/2024 11:30:00 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 07/30/2024 09:20:53 PM
- Anavex Life Sciences Announces Translational Biomarker Data for ANAVEX®2-73 (blarcamesine) in Fragile X Syndrome (Major Cause of Autism) at the 19th NFXF International Fragile X Conference • GlobeNewswire Inc. • 07/30/2024 11:30:00 AM
- Form S-3 - Registration statement under Securities Act of 1933 • Edgar (US Regulatory) • 07/29/2024 09:21:49 PM
- Results from Anavex Life Sciences Landmark Phase IIb/III Trial of Blarcamesine Presented at Alzheimer's Association Conference • GlobeNewswire Inc. • 07/28/2024 09:00:00 PM
- Anavex Life Sciences to Present at the H.C. Wainwright 5th Annual Neuro Perspectives Virtual Conference • GlobeNewswire Inc. • 06/20/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/17/2024 11:30:10 AM
- Anavex Life Sciences Announces Expansion of Leadership Team • GlobeNewswire Inc. • 05/22/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/17/2024 10:01:00 AM
- Anavex Life Sciences to Present at the H.C. Wainwright 2nd BioConnect Investor Conference at NASDAQ • GlobeNewswire Inc. • 05/14/2024 11:30:00 AM
- Shareholders that lost money on Anavex Life Sciences Corporation(AVXL) Urged to Join Class Action - Contact The Gross Law Firm to Learn More • PR Newswire (US) • 05/10/2024 09:45:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/09/2024 08:35:55 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/09/2024 12:00:30 PM
- Anavex Life Sciences Reports Fiscal 2024 Second Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 05/09/2024 11:30:00 AM
- The Gross Law Firm Announces the Filing of a Securities Class Action on Behalf of Anavex Life Sciences Corporation(AVXL) Shareholders • PR Newswire (US) • 05/07/2024 09:45:00 AM
- Form DEFA14A - Additional definitive proxy soliciting materials and Rule 14(a)(12) material • Edgar (US Regulatory) • 05/06/2024 10:03:33 AM
- Anavex Life Sciences Corporation Sued for Securities Law Violations - Contact The Gross Law Firm Before May 13, 2024 to Discuss Your Rights - AVXL • PR Newswire (US) • 05/03/2024 09:45:00 AM
- Anavex Life Sciences to Announce Fiscal 2024 Second Quarter Financial Results on Thursday, May 9th, 2024 • GlobeNewswire Inc. • 05/02/2024 11:30:00 AM
- May 13, 2024 Deadline: Contact The Gross Law Firm to Join Class Action Suit Against AVXL • PR Newswire (US) • 04/26/2024 09:45:00 AM
- Contact The Gross Law Firm by May 13, 2024 Deadline to Join Class Action Against Anavex Life Sciences Corporation(AVXL) • PR Newswire (US) • 04/19/2024 09:45:00 AM
- The Gross Law Firm Reminds Shareholders of a Lead Plaintiff Deadline of May 13, 2024 in Anavex Life Sciences Lawsuit - AVXL • PR Newswire (US) • 04/16/2024 09:45:00 AM
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