Upgrades: American Equity Investment Life (AEL) upgraded to Outperform from Mkt Perform at Keefe Bruyette; tgt $42 Ardelyx (ARDX) upgraded to Buy from Neutral at Ladenburg Thalmann; tgt $6 Brixmor Property (BRX) upgraded to Market Perform from Underperform at BMO Capital Markets; tgt $25 Capital One (COF) upgraded to Neutral from Underperform at Robert W. Baird; tgt $145 DoorDash (DASH) upgraded to Buy from Hold at Gordon Haskett; tgt $217 Grupo Aeroportuario Del Sureste (ASR) upgraded to Neutral from Sell at Goldman; tgt raised to $225 Downgrades: American Water Works (AWK) downgraded to Underweight from Equal Weight at Wells Fargo; tgt lowered to $170 Krispy Kreme, Inc. (DNUT) downgraded to Sell from Neutral at Goldman; tgt lowered to $14 Others: Alkermes (ALKS) initiated with a Neutral at Citigroup; tgt $22 Caribou Biosciences (CRBU) initiated with an Outperform at Oppenheimer; tgt $36 CNH Industrial (CNHI) resumed with an Overweight at JP Morgan; tgt raised to $20 CVS Health (CVS) initiated with a Buy at Seaport Research Partners; tgt $110