RespireRx Pharmaceuticals Inc (fka RSPI)

[striaterminalis]

"As a pathologist I am not as comfortable with the apparent lack of changes in the frozen tissues sections as Mr. Stoll would seem to be. This process is not as sensitive as the paraffin-based histology and it is still possible that a real lesion is there."

Can you elaborate on what types of changes the flash freeze processing is not as sensitive to? I would be interested. It seems to me that, if done right, freezing would be less subject to artifcat and be equally sensitive if sections are post fixed in the appropriate buffers with paraformaldehyde or glutaraldehyde, etc...

I hope COR was not stupid enough to create some sort of osmotic artifact during processing.

What mystifies my still is why any after death changes in tissue would be selective for a high dose of the compound. As a pathologist, do you have any guesses?

Thanks in advance for any insights.