Anavex Life Sciences Corp (AVXL)

[end2war]

It is my understanding that activation of SR1 and Muscarine Receptors impacts different passageways depending on where the trouble is that the receptor is working on. The resultant action also depends on where the receptor is located.

If the receptor is in the ER, and parts of the ER are out of balance, then you get a tune up of those parts of the ER when those receptors are activated.

But if the receptor is focused on problems in the neuron, such as neurofibrillary tangles due to tau being hyperphosphorylated, such activation may protect some of the neurons or microtubules from damage or restore partially damaged functions.

Or, if there is a lysosome malfunction, and there is a buildup of matter that needs to be removed for optimum function, then activation of these receptors turns on the autophagy housecleaning functions.

Activation of these housecleaning, maintenance or repair receptors are probably the result of evolutionary processes that were created, i.e., evolved, based on the need to guide what repairs are attempted for cell survival.