Anavex Life Sciences Corp (AVXL)

[nidan7500]

abew4me:

Here's a quote from TGD at the H.C. Wainwright 23rd Annual Global Investment Conference last month...at the 12:40 minute mark:

"But the most important distinction of A2-73 and the entire platform of sigma-1 activation is that we've now been able to learn, very recently, that sigma-1 activation goes even further upstream into the nucleus...and its been able to show that it prevents cellular stress before and after RNA translation.

So in regards to that, chromatin remodeling is restored, as well as post-translation proteins - which are toxic - are prevented, by preventing toxic RNA to be expressed into toxic proteins. So only healthy proteins are expressed by expressing healthy RNA".


https://journey.ct.events/view/48684630-6af2-4c12-a206-f94233cde440

powerful stuff-observation, IMO. I also often think about the PDD "stop the action" "late breaking" FDA moment in LA months ago, then NADA-zippo..a giant "So WHAT" moment. HUH, these pieces among others do not yet fit into the current status quo. Regulatory bodies do not do such things unless they have a good reason.

This kinda fits w/my own sense that our period of AVXL top down silent observation must be tied to FDA discussions. Even if we have our issues w/their 30+ year Amyloid giant dead end that are unresolved , unless they can work a deal w/AVXL that allows for them to retain a level of credibility while the science moves forward. IMO, there are serious (but not yet fatal) consequences to all this that must be worked out. (FDA live in a time-space continuum different than the rest of us). That is what will continue until a way out can be agreed. ALL IMO.

Once the management cliff hanger is worked out then ..."stand back" a bunch of new science-trial information and plans can be made public. We are in this up to our eyeballs and FDA-(other WW regulatory bodies) are awaiting the all clear-launch signal.

Would like to speculate also that FDA have learned that politics and medical science should not ever be mixed, reactions can be extreme and explosive. I guess we will know it when we see it b/c this will be a different kind of process news which will/should allow-promote win-wins.