Anavex Life Sciences Corp (AVXL)

[falconer66a]

Speak for yourself.

And we don't even know if 3-71 is efficacious in human disease yet,....

Well, you are welcome to maintain ignorance of the outcomes of blarcamesine dosings in a number of clinical trials.

Of course, three clinical trials testing the safety and efficacies of blarcamesine for a) Rett syndrome, b) Parkinson's disease dementia, and c) Alzheimer's disease are currently in operation. Later, Anavex 3-71 will have human clinical trials.

Some observers of new drug development rather arbitrarily claim (as in this case) that it is impossible to know if a new drug candidate will actually treat any sort of disease until FDA-approved clinical trials are completed.

Those with that perspective should, of course, avoid Anavex and AVXL shares until the FDA grants full approval. Taking an AVXL position on what pre-clinical studies, in mice of all things, reveal is presumed to be unwise.

Others (many who visit and usefully contribute to this message board) take a different view of Anavex, blarcamesine, and Anavex 3-71. We closely scrutinize the many studies of these drugs, and are certain that they accurately presage eventual FDA approvals.

Two Anavex viewpoints.

1. STAY AWAY. Efficacy in humans can't possibly be known until proper, accepted clinical trials are completed. Therefore, diligently decide to avoid an AVXL position of any size. Wait until Anavex gets FDA approvals.

2. CAREFULLY INVEST. The many good studies of blarcamesine and other Anavex sigma-1 receptor agonists, in murines (lab rodents) with parallel or analogous human disease genotypes (transgenic murine models) accurately reveal the drugs' mechanisms of action, which will likewise occur in humans.

With perspective 1, all is safe and settled. There is no Anavex story to be aware of, or exploit for investment advantage until FDA trials are both completed and with positive therapeutic results.

With perspective 2, shares of AVXL can be carefully purchased at prices far lower than after the drugs attain FDA approval. A great investment advantage.