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Re: Dr Bala post# 374201

Monday, 05/03/2021 3:33:25 PM

Monday, May 03, 2021 3:33:25 PM

Post# of 822498

I consider the people that you mentioned (Flipper and Senti) to be experts in the trial and they both are convinced of the success of the trial.


I bet if you asked them they would say they are cautiously optimistic.

I don't think they would say they are "convinced" the trial will be a success.

having said that, LOL, I think the trial (as modified to use a BS endpoint) will very likely be a "success".

A "success" lacking scientific validity though.

"A Successful trial is one that provides a reliable answer to the question it addresses." Tom Fleming

So, with the modification to using a historical control, and Fleming's definition, I would say that no, the trial will not be a success (because the answer will not be reliable).



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