Monday, May 03, 2021 1:58:28 PM
I am not saying that is impossible, but it would be difficult.
First, what you need are reasonably similar trials in that the enroll after the initial chemo-rad.
Now, where it gets really difficult is that what you want is the individual patient data so you can look at all the key factors and do what is called a multivariate cox analysis.
Problem is, that presupposes you have access to the raw patient data, which you do not.
The only attempt I have seen to solve this was trying to generate some ideal model based on all known data. And then weight the comparator trials by these factors.
All of this type stuff has a huge bunch of knobs to turn to get the answer. That is why it needs to really locked down in advance.
None of this is what the UK and German study say though. Maybe NWBO can answer at the ASM. LOL.
First, what you need are reasonably similar trials in that the enroll after the initial chemo-rad.
Now, where it gets really difficult is that what you want is the individual patient data so you can look at all the key factors and do what is called a multivariate cox analysis.
Problem is, that presupposes you have access to the raw patient data, which you do not.
The only attempt I have seen to solve this was trying to generate some ideal model based on all known data. And then weight the comparator trials by these factors.
All of this type stuff has a huge bunch of knobs to turn to get the answer. That is why it needs to really locked down in advance.
None of this is what the UK and German study say though. Maybe NWBO can answer at the ASM. LOL.
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