Anavex Life Sciences Corp (AVXL)

[abew4me]

No. You can't equate Pridopidine's results (or any other sigma-1 receptor agonist drug) with A2-73 because each S1-R agonist drug binds to the Sigma-1 receptor in a different way.

Below is a partial list of other sigma-1 receptor agonist drugs:

PRE-084
Donepezil
Fluvoxamine
Citalopram
Amitriptyline
L-687,384
SA-4503
Dextromethorphan
Dimethyltryptamine

Each one of these Sigma-1 receptor agonist drugs binds to the sigma-1 receptor differently...and, for the most part, causes a different outcome.

A very popular drug listed above is Fluvoxamine. Below is a partial list of its side effects:

Loss of appetite
Agitation
Nervousness
Anxiety
Insomnia

As you know, participants in almost every study using A2-73 has reported sleeping better...which is the opposite of insomnia.

As I stated before, Anavex has several patents on their drugs because they have figured out the best way to bind to the sigma-1 receptor. (In my opinion, of course)

To quote from wikipedia:
"Also, sigma-1 receptors have been shown to appear in galactoceramide enriched domains at the endoplasmic reticulum of mature oligodendrocytes.[24] The wide scope and effect of ligand binding on sigma-1 receptors has led some to believe that sigma-1 receptors are intracellular signal transduction amplifiers.[14]"

Bottom line: Not all sigma-1 receptor drugs are alike...and therefore their results should not be compared equally to each other.


abew4me "abe"