Anavex Life Sciences Corp (AVXL)

[falconer66a]

Ponder, the pancellular activities of Anavex 2-73!

The more I read about our MOA the more convinced I am that this theme will continue in other human systems also.

Ok, Nidan, well said; something that I've been reluctant to expound upon. The significance of the Anavex sigma-1 receptor agonists (activators) is now becoming clear, in particular reference to their propitious activities in diseased neurons. Well and good (well, EXCEPTIONAL).

But, sigma-1 receptors are not at all unique to neurons, nerve cells. Of course, in those cells restoration of normalized sigma-1 receptor activities restores normalized neuron functions, nerve-cell health. Hence, the ability of blarcamesine (Anavex 2-73) to profoundly treat or prevent various central nervous system (CNS) diseases. Medical science in the 21st century will be transformed.

But, consider, not only just the CNS pathologies being investigated. This new matter has been little discussed yet –-- but if a) sigma-1 receptors are in all cells that have active mitochondria and endoplasmic reticula (the actual case), and b) the Anavex drugs will act, then, on sigma-1 receptors in the broad diversity of non-nerve cells in the body, what other human pathologies caused by poor sigma-1 receptor activation might blarcamesine (and the other Anavex drugs) be able to treat?

Is the Anavex mechanism of action (MOA) confined only to malfunctioning nerve cells, or does it operate also in a wide diversity of the cells of other tissues and organs? Might "pancellular" (in all cells) sigma-1 receptor activation by Anavex drugs treat or prevent a much larger body of diseases and conditions; beyond those presently being targeted in the CNS?

If so, the Anavex MOA is not an iceberg treating only CNS diseases. It's an entire continental (organism-wide) glacier, moving slowly but with exceptional force against a yet to be discovered diversity of diseases and conditions not residing in the CNS.