Interesting info regarding Patents applied for by NWBO, including this one below granted to NWBO in August 2020. (Note: Boynton & Bosch were often listed under Inventors, but lots of other inventors mentioned as well).
Generation of dendritic cells from monocytic dendritic precursor cells with GM-CSF in the absence of additional cytokines Patent number: 10731130 Abstract: The present invention it was determined that dendritic cells could be derived from various sources including peripheral blood monocytes in the presence of only GM-CSF without other cytokines if the monocytes were not activated. By preventing activation, such as by preventing binding of the cells to the surface of the culture vessel, the monocytes do not require the presence of additional cytokines, such as IL-4 or IL-13, to prevent differentiation into a non-dendritic cell lineage. The immature DCs generated and maintained in this manner were CD14 and expressed high levels of CD1a. Upon maturation by contact with an agent such as, for example, BCG and IFN?, the cells were determined to express surface molecules typical of mature dendritic cells purified by prior methods and cultured in the presence of GM-CSF and IL-4. Type: Grant Filed: July 30, 2015 Date of Patent: August 4, 2020 Assignee: NORTHWEST BIOTHERAPEUTICS, INC. Inventors: Benjamin A. Tjoa, Marnix L. Bosch
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