I have a great deal of respect for AVII as well, but I believe he had a personal involvement in this case and advised someone with the disease to take a different course. It's hard to admit you may have been wrong when someone's life was on the line.
I believe after he's seen the data he'll become a fan, but time will tell.
If prostate surgery would give adequate material, is it the opinion of those here that DCVax-L would be at least as effective as Provenge.
Prostate is often one of the slowest growing cancers, often surgery isn't performed, especially in senior patients as they could often die of other causes before prostate would be a problem. I had an uncle who was treated in that way. That said, I would think that DCVax-Direct would be ideal in this application, even if it were operable, but the choice was made not to. It's said that if most men live long enough, they'll get prostate cancer.
The problem with running a DCVax-Direct trial in prostate is that it's so slow moving, the trial would need to be very large and could take decades to gain meaningful results. I suspect that if DCVax-Direct is approved for a number of more aggressive cancers it will be applied to prostate without further proof. If in fact DCVax-Direct was proved to halt the growth of prostate cancer with essentially no negative side effects, I believe that many men would opt to give it a try before using other forms of therapy because of the side effects.
Out of curiosity, how long does it take to go from leukapheresis to having DCVax-Direct ready to dose. We all take cancer very seriously, but experience has shown me that once discovered, surgery often takes one to two months to schedule and execute. I know in both my, and my wife's case, it was over a month. If DCVax-Direct can be made in days, or weeks, it might very well be used prior to surgery as the SOC. DCVax-L could be made from the tumor and used in treatment, and should tumors reoccur, new DCVax-Direct might very well be applied.
I'm uncertain, but believe leukapheresis only takes a matter of hours, or a couple days at most. I know when stem cells are donated they are gathered in 1 to 3 days in a similar manner unless the donor wishes to have the cells removed from the marrow, which is much more painful, but quicker.
Out of curiosity, does anyone know if the time to produce the vaccine is faster with the new devices the company just acquired, or is it primarily lowering the cost of doing so.
Gary
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