Friday, October 02, 2020 3:50:21 PM
DCVax-L TLD results will be positive no matter what:
With the blinded data we already have, and the last patient in Nov 2015, there is enough information already to show DCVax-L is a good investment. Here are my reasons:
1) We know that over 25% of the patients treated are showing a PFS greater than 15 months
2) Blinded OS results are so good that the only way the OS fails to meet the 2 months increase in OS, means that the crossed over patients lived longer than SOC patients normally do, and this could be compared to SOC for approval.
3) Both the blinded data from methylated and unmethylated MGMT patients show significant increases from Blinded Optune patients (~ 7 months unmethylated and 10 months meythlated), which means that this sub group in itself could provide an approval path with the FDA.
And lastly, if the mOS increase doesn't meet the 2 months there is enough subset data, and overall trial increase as seen from blinded results that Linda Powers will easily be able to sell NWBO's proprietary technology to the highest Big Pharma bidder, which would easily be between $10B and $20B.
ITS A WIN-WIN-WIN-WIN situation, atleast IMHO!
With the blinded data we already have, and the last patient in Nov 2015, there is enough information already to show DCVax-L is a good investment. Here are my reasons:
1) We know that over 25% of the patients treated are showing a PFS greater than 15 months
2) Blinded OS results are so good that the only way the OS fails to meet the 2 months increase in OS, means that the crossed over patients lived longer than SOC patients normally do, and this could be compared to SOC for approval.
3) Both the blinded data from methylated and unmethylated MGMT patients show significant increases from Blinded Optune patients (~ 7 months unmethylated and 10 months meythlated), which means that this sub group in itself could provide an approval path with the FDA.
And lastly, if the mOS increase doesn't meet the 2 months there is enough subset data, and overall trial increase as seen from blinded results that Linda Powers will easily be able to sell NWBO's proprietary technology to the highest Big Pharma bidder, which would easily be between $10B and $20B.
ITS A WIN-WIN-WIN-WIN situation, atleast IMHO!
Recent NWBO News
- CNS Drug Delivery Breakthroughs Unlock Significant Biotech Market Opportunities • InvestorsHub NewsWire • 05/11/2026 01:00:00 PM
- CNS Drug Delivery Breakthroughs Unlock Significant Biotech Market Opportunities • GlobeNewswire Inc. • 05/11/2026 12:30:00 PM
- Northwest Biotherapeutics Appoints Dr. Annalisa Jenkins As Strategic Adviser To Advance Dendritic Cell Cancer Vaccine Platform • PR Newswire (US) • 04/30/2026 04:38:00 PM
- Northwest Biotherapeutics Appoints Dr. Annalisa Jenkins As Strategic Adviser To Advance Dendritic Cell Cancer Vaccine Platform • PR Newswire (US) • 04/30/2026 04:30:00 PM
- Northwest Biotherapeutics Announces Establishment Of the Company's Own Dedicated Leukapheresis Clinic • PR Newswire (US) • 04/21/2026 01:30:00 PM
- Northwest Biotherapeutics Announces Establishment Of the Company's Own Dedicated Leukapheresis Clinic • PR Newswire (US) • 04/21/2026 01:30:00 PM
- Form EFFECT - Notice of Effectiveness • Edgar (US Regulatory) • 04/21/2026 04:15:08 AM
- Form POS AM - Post-Effective amendments for registration statement • Edgar (US Regulatory) • 04/16/2026 09:25:30 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 04/07/2026 04:30:50 PM
- Form NT 10-K - Notification of inability to timely file Form 10-K 405, 10-K, 10-KSB 405, 10-KSB, 10-KT, or 10-KT405 • Edgar (US Regulatory) • 03/31/2026 09:04:37 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 01/15/2026 10:06:20 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 01/02/2026 10:14:59 PM
- Form DEF 14A - Other definitive proxy statements • Edgar (US Regulatory) • 11/28/2025 09:43:27 PM
- Form 424B5 - Prospectus [Rule 424(b)(5)] • Edgar (US Regulatory) • 11/25/2025 10:23:07 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 11/20/2025 09:26:03 PM
- Form PRE 14A - Other preliminary proxy statements • Edgar (US Regulatory) • 11/19/2025 09:15:48 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 11/14/2025 09:44:21 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 10/31/2025 04:29:10 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 10/30/2025 08:40:05 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 10/24/2025 04:28:38 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 10/14/2025 06:22:26 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/14/2025 09:00:38 PM
- Form 424B5 - Prospectus [Rule 424(b)(5)] • Edgar (US Regulatory) • 07/01/2025 09:04:38 PM
