I agree. It's too close to the election. That would make it impossible to do. Though were it to happen, there's no guarantee that a President Pence would be reelected. I don't have the sense he's made much of an impression on the electorate.
However, to the issue of the 25th amendment, or putting pressure on Trumpty to resign, George Will was just on Chuck Todd's show. Yesterday, he wrote an article saying Trump must be removed, and advocating the removal of a number of Congressional Republican as well.
But he says the Republicans who've called him in reaction--old friends--are in denial.