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[Vexari]

This Natural Amino Acid Impairs Coronavirus Replication

Just like it does on cold sores i.e. Herpes Simplex Virus

Plus another amino acid Glycine

D, L-lysine acetylsalicylate + glycine


Abstract


Coronaviruses (CoV) belong to the large family Coronaviridae within the order of Nidovirales. Among them, several human pathogenic strains (HCoV) are known to mainly cause respiratory diseases. While most strains contribute to common cold-like illnesses others lead to severe infections. Most prominent representatives are SARS-CoV and MERS-CoV, which can lead to fatal infections with around 10% and 39% mortality, respectively. This resulted in 8098 casualties in the 2002/2003 SARS-CoV outbreak and in 1806 documented human infections (September 2016) during the recent ongoing MERS-CoV outbreak in Saudi Arabia. Currently patients receive treatment focusing on the symptoms connected to the disease rather than addressing the virus as the cause. Therefore, additional treatment options are urgently needed which would ideally be widely available and show a broad affectivity against different human CoVs. Here we show that D, L-lysine acetylsalicylate + glycine sold as " Asprin i.v. 500mg® " (LASAG), which is an approved drug inter alia in the treatment of acute pain, migraine and fever, impairs propagation of different CoV including the highly-pathogenic MERS-CoV in vitro. We demonstrate that the LASAG-dependent impact on virus-induced NF-?B activity coincides with (i) reduced viral titres, (ii) decreased viral protein accumulation and viral RNA synthesis and (iii) impaired formation of viral replication transcription complexes.



D, L-lysine acetylsalicylate + glycine Impairs Coronavirus Replication

Christin Müller, Nadja Karl, John Ziebuhr and Stephan Pleschka*
Institute of Medical Virology, Justus Liebig University Giessen, Schubertstr 81, 35392 Giessen, Germany

*Corresponding author: Stephan Pleschka, Institute of Medical Virology, Schubertstr. 81, 35392 Giessen, Germany, Tel: 0049 (0)641-99-47750; Fax: 0049
(0)641-99-41209; E-mail: [e-mail]

Received date: December 05, 2016, Accepted date: December 20, 2016, Published date: December 30, 2016

Copyright: © 2016 Müller C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original author and source are credited



Abstract

Coronaviruses (CoV) belong to the large family Coronaviridae within the order of Nidovirales. Among them,
several human pathogenic strains (HCoV) are known to mainly cause respiratory diseases. While most strains
contribute to common cold-like illnesses others lead to severe infections. Most prominent representatives are SARS-
CoV and MERS-CoV, which can lead to fatal infections with around 10% and 39% mortality, respectively. This
resulted in 8098 casualties in the 2002/2003 SARS-CoV outbreak and in 1806 documented human infections
(September 2016) during the recent on-going MERS-CoV outbreak in Saudi Arabia. Currently patients receive
treatment focusing on the symptoms connected to the disease rather than addressing the virus as the cause.
Therefore, additional treatment options are urgently needed which would ideally be widely available and show a
broad affectivity against different human CoVs. Here we show that D, L-lysine acetylsalicylate + glycine sold as
“Asprin i.v. 500mg®” (LASAG), which is an approved drug inter alia in the treatment of acute pain, migraine and
fever, impairs propagation of different CoV including the highly-pathogenic MERS-CoV in vitro. We demonstrate that
the LASAG-dependent impact on virus-induced NF-?B activity coincides with (i) reduced viral titres, (ii) decreased
viral protein accumulation and viral RNA synthesis and (iii) impaired formation of viral replication transcription
complexes