Tuesday, January 07, 2020 5:54:05 PM
Well. If you were right about only one patient's cells in a cleanroom at a time, they would need an awful lot of cleanrooms...
I therefore assume you must be wrong.
IIRC, they did a slide presentation at Phacilitate in Jan '19, which went into a degree of detail about the manufacturing process, and stated something about further manufacturing refinement meant that only 1 gram (I think) of tumor material was now needed for batch production, and they mentioned (I think) potential production capacity for Sawston (or might have been Memphis) in the tens of thousands. Which of course could not be the case, if what you asserted was accurate.
So I'll do the same as you and assert you must be wrong, then humbly withdraw my remarks if you are proved correct.
Unfortunately that slide deck, which was available on the NWBO website, appears to no longer be there.
Don't know if anybody retained it or can find it.
On the broader point: Of course, there comes a point with increasing demand you have to scale up or scale out.
But we all know this. And you expand when you are able to or when you have to.
As we know, the Car-T manufacturing process, after approval, has run into big problems. Their manufacturing still runs at 3 weeks, and they have had problems with lots of their autologous product failing QC parameters.
The whole CMC arena is what we are talking about here. And I assume NWBO are on to it.
Because if they are not, then we've got problems...
But they've long known that 'the process is the product' and have been working on streamlining production for many years.
They believe they are ahead of competitors in this regard, not behind.
I therefore assume you must be wrong.
IIRC, they did a slide presentation at Phacilitate in Jan '19, which went into a degree of detail about the manufacturing process, and stated something about further manufacturing refinement meant that only 1 gram (I think) of tumor material was now needed for batch production, and they mentioned (I think) potential production capacity for Sawston (or might have been Memphis) in the tens of thousands. Which of course could not be the case, if what you asserted was accurate.
So I'll do the same as you and assert you must be wrong, then humbly withdraw my remarks if you are proved correct.
Unfortunately that slide deck, which was available on the NWBO website, appears to no longer be there.
Don't know if anybody retained it or can find it.
On the broader point: Of course, there comes a point with increasing demand you have to scale up or scale out.
But we all know this. And you expand when you are able to or when you have to.
As we know, the Car-T manufacturing process, after approval, has run into big problems. Their manufacturing still runs at 3 weeks, and they have had problems with lots of their autologous product failing QC parameters.
The whole CMC arena is what we are talking about here. And I assume NWBO are on to it.
Because if they are not, then we've got problems...
But they've long known that 'the process is the product' and have been working on streamlining production for many years.
They believe they are ahead of competitors in this regard, not behind.
Recent NWBO News
- Northwest Biotherapeutics Announces Establishment Of the Company's Own Dedicated Leukapheresis Clinic • PR Newswire (US) • 04/21/2026 01:30:00 PM
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- Form POS AM - Post-Effective amendments for registration statement • Edgar (US Regulatory) • 04/16/2026 09:25:30 PM
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- Form NT 10-K - Notification of inability to timely file Form 10-K 405, 10-K, 10-KSB 405, 10-KSB, 10-KT, or 10-KT405 • Edgar (US Regulatory) • 03/31/2026 09:04:37 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 01/15/2026 10:06:20 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 01/02/2026 10:14:59 PM
- Form DEF 14A - Other definitive proxy statements • Edgar (US Regulatory) • 11/28/2025 09:43:27 PM
- Form 424B5 - Prospectus [Rule 424(b)(5)] • Edgar (US Regulatory) • 11/25/2025 10:23:07 PM
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- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 11/14/2025 09:44:21 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 10/31/2025 04:29:10 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 10/30/2025 08:40:05 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 10/24/2025 04:28:38 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 10/14/2025 06:22:26 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/14/2025 09:00:38 PM
- Form 424B5 - Prospectus [Rule 424(b)(5)] • Edgar (US Regulatory) • 07/01/2025 09:04:38 PM
