Anavex Life Sciences Corp (AVXL)

[BAR123]

Great find Jorge. If you read through this patent it clearly states that a 273 with 5 mg or less is synergistic with Donepezil. Do you know what this means. We will be having many partnership coming up Below is from the patent about half way down.

It is a particular advantage of the combination of A19/2 and AED is that, in combination with A19-144 or A2-73, sub-MED doses of AED are therapeutically effective. AED's are implicated in memory loss in subjects taking AED's. Lower AED doses result is absent or lessened memory loss or memory impairment.

In some embodiments, the AED is donepezil, with reference to donepezil at from about 0.5 mg to about 23 mg, and particularly from about 0.5 mg to less than about 5 mg, and more particularly from about 1 to about 3.5 mg. With the synergistic effect in combination with A19-144 or A2-73, doses below 0.5 mg are effective.