I agree that the use of 5-ALA-FIGR (Topical 5-aminolevulinic acid - Fluorescence image guided surgical resection.) is a good tool for improving the immunogenicity of cancer cells (Immunogenic apoptosis and the exposure on the plasma membrane of DAMPs = Damage associated molecular pattern) to use them as an antigen cargo in the development of dendritic cell (DC) vaccines.
I wonder if Fraunhofer improved the manufacturing process to obtain a more immunogenic DCvax-L?
I hope that a DCvax-L that is more immunogenic can induce an immunostimulatory shift in the brain immune environment, leading to reduced numbers of regulatory T cells and increased prevalence of Th1, CTLs, and Th17 lymphocytes. Anyway that's what Hyp-PDT-TCL-loaded DC vaccines do.
hypericin-based photodynamic therapy (Hyp-PDT) tumor cell lysate (TCL) regulatory T cells (also called Tregs) are T cells which have a role in regulating or suppressing other cells in the immune system. Cytotoxic T lymphocyte (CTL) T helper cells (Th cells) = a type of lymphocytes that play an important role in the immune system.
Manufacture of the immunotherapeutic DCVax®-L for brain tumor patients.
The manufacturing process for the immunotherapeutic DCVax®-L has been optimized and implemented as part of a clinical trial conducted by American biotech company Northwest Biotherapeutics, Inc. The therapeutic approach is based on autologous dendritic cells and aims to improve the treatment of glioblastoma, a particularly aggressive type of brain tumor. https://www.izi.fraunhofer.de/content/dam/izi/en/documents/Publications/AnnualReport_IZI_2017_short.pdf
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