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Re: polarbear77 post# 209434

Friday, 09/13/2019 6:36:22 AM

Friday, September 13, 2019 6:36:22 AM

Post# of 519023
Listened and was glad to hear Misslings PM description.

He is not saying that the WT vs variant Sigma-1 gene findings are to select patients thereby increasing chance of success. Instead the highly stat sig finding is another clear confirmation that the Sigma-1 MOA target is activated for efficacy by a2-73.

This along with the RNA expression confirmation adds some weight against the concern that the study was not placebo controlled.
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