Anavex Life Sciences Corp (AVXL)

[jimmy667]

The weaker the signal the higher the n or trial participants needs to be to show Stat Sig.
For instance Naloxon (Narcan) works instantly almost every time to reverse opiod overdose. Opioid overdose affects very large numbers of unfortunate victims but is certainly did not take a large trial with thousands to prove effective because of the strength of the signal.
With the Biogen drugs the signal was weak and proved to be almost nonexistant no matter how large they expanded the n.
Stubborn headed arrogance is almost always a bad idea.
A2-73 shows a fairly large signal in all preclinical work and with the human trials where the higher blood concentrations were achieved.
Find the way to consistently achieve therapeutic blood concentrations of A2-73 then as Biostockclub retorts "We got this." I believe this was the thrust and the importance of the gut biome work.
Therefore as the ALZ and PDD trials proceed it maybe that the n can be smaller and therefore a less lengthy trial than originally conceived if the signal is strong and the way to achieve the proper blood concentrations of A2-73 and is longer acting active metabolite.

Some complain wow this is taking so long. But remember as our clinical success mounts our IP patent protection must keep pace. I believe the delibrate pace of the drug development was designed not to out run the patent developments.

Some complain that Missling remains so quiet running a tight ship and divulging little information. Running silent and deep like a submarine. Same as above protecting the IP. I find it anything rather than ironic that the Anavex drug shares the same alpha numeric designation as the Polaris II. The first seaborne missile designed to fire from a submerged position. A2-73 was not the drugs first alpha numeric designation. It was renamed. Connect the dots. When Anavex ignites it almost assuredly fire from a submerged position with two stages and a powerful payload.

Chew on that! At some point AVXL will go ballistic faster than one can say Lockheed!