Anavex Life Sciences Corp (AVXL)

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Some take aways from the many Dr. Barrett touches on:

-What is a Sigma 1 receptor?

"A ligand regulated molecular membrane chaperone.
Chaperones are protein components that form various associations that are functional.
It’s one of the most powerful systems for regulating protein folding and aggregation for maintaining protein homeostasis in the mitochondria and in the endoplasmic reticulum.
It’s expressed to a large extent in the ER located at the interface with the mitochondria."

Dr. Barrett on the cost of pain:

"Pain is a significant unmet medical need. It’s the most prevalent and expensive public health problem in the developed World. The economic costs exceed the combined costs of cancer, heart disease and diabetes combined so it is a significant problem."

And opioids:

"We are in the midst of a severe opioid epidemic and crisis where in 2016 over 64,000 people have died from opioid overdose. The idea of developing an effective analgesic that’s as good as what we have available. And what we have available isn’t all that good sometimes is a high unmet medical need."