Anavex Life Sciences Corp (AVXL)

[makemydaze]

Thanks Greenspam3 for the patent update re: AV1066.

https://patentscope.wipo.int/search/en/detail.jsf;jsessionid=BC408884301C92C138395C4C99A39D55.wapp1nC?docId=US243292967&tab=PCTDESCRIPTION&office=&prevFilter=&sortOption=Pub+Date+Desc&queryString=FP%3A%28anavex%29&recNum=1&maxRec=38

Here's part of the verbiage from the patent claims(from the link above):

"Without being bound by any particular theory, AV-1066 has a positive effect on the hypersensitivity likely due to the nerve constriction. At any moment, treated animals with AV-1066, whatever the dose, came back to values observed to the intact hind paw (max effect+59%)."

and from the poster presentation for 1066:

• AV1066 produced a dose-dependent reversal of the hypersensitivity that develops in animal models of both neuropathic and visceral pain.

• The reversal of the hypersensitivity with AV1066 appeared to be complete as drug treated levels and vehicle-treated / sham levels were indistinguishable. • AV1066 had no significant effect on the rate of intestinal transit, a surrogate marker for constipation, at doses in which it relieved visceral pain, and demonstrated only a limited effect in the Irwin Grid, a behavioral battery commonly used in estimating general safety and toleration.

In the CCI model of neuropathic pain, AV1066 did not impact nociception in the contralateral healthy paw in contrast to morphine, which has an analgesic effect in both paws. This suggests that AV1066 acts in a state-selective manner and only impacts nociception during periods of pathophysiological stress.

http://www.anavex.com/wp-content/uploads/AV-1066-poster-November-2016.pdf

The bolded part(which I highlighted) has me wondering if there is any oral heavy duty pain reliever that only affects the part of the body that is experiencing pain? I'm of the opinion that most available heavy duty oral pain medications have a whole body effect but I'm no authority.

And it looks like 1066 may have anti-tumor as well:

"ANAVEX 1066, a mixed Sigma-1/Sigma-2 receptor ligand, has previously demonstrated antitumor activity as well as analgesic effects in an animal model of chemotherapy-induced polyneuropathy."

https://www.globenewswire.com/news-release/2016/11/14/889538/0/en/Anavex-Life-Sciences-Novel-Sigma-1-Sigma-2-Ligand-Shows-Encouraging-Results-as-an-Analgesic-in-Animal-Models-of-Neuropathic-and-Visceral-Pain.html

The potential of this sigma receptor platform is off the charts. IMO