Anavex Life Sciences Corp (AVXL)

[F1ash]

Digressing slightly - This extended activation period of the Sigma-1 Receptor perhaps holds an answer to why DPZ co-administration in smaller doses is ok despite its higher affinity e.g. DPZ is metabolised quicker and leaves the biological system well before A19-144

What is the basis for your above statement?


“The elimination half-life of Donepezil is about 70 hours, and the mean apparent plasma clearance (Cl/F) is 0.13 to 0.19 L/hr/kg. Following multiple dose administration, Donepezil accumulates in plasma by 4 to 7 fold, and steady state is reached within 15 days. The steady state volume of distribution is 12 to 16 L/kg

https://www.drugs.com/pro/donepezil.html