Anavex Life Sciences Corp (AVXL)

[jimmy_mcyoloswag]

My last 2 cents and then I‘m off to the holidays:

I would assume varying affinities / binding sites and activation levels of the receptor by the different compounds would change their effectiveness combatting symptoms as drugs.

Another factor would be cross-activation/inhibition of other impactful receptors.

Maybe unintended co-activation is needed/favorable, maybe pure and high affinity activation is key.

It would be interesting to compare the affinities of 2-73 and 3-71 to the SR1 and to other CNS receptors (like NMDA, GABAR etc..). My guess is 3-71 has a higher affinity and specificity for SR1.

In other terms: we‘re playing chords and need to find the note that causes the strongest resonance in our target glass.

Happy holidays y‘all!