"The brilliance (I claim) of the AVXL trial plan w/PDD and RS is it should show the MOA (thx XENA) demonstrated in these should show/demonstrate FUNCTIONAL (sleep, spasm, movement range, etc) results which are more easily and accurately measured early on a time line.
The end points will demonstrate this plan and (IMO) RWE/RWD will support along w/caregiver reports and anecdotes. So what you say, We already knew that.
So, before the dementia curtain starts to come down on AD patients valuable time is lost, we have to get that back while we try to develop biomarkers that really tell us something. IMO, that is what is going on right now while we wait for the trials to start.
Since AD stage cannot yet be measured w/confidence (functional) until it is too late the PDD/RS trials are vicariously on the point while the AD debate of function vs cognition rages for stage 1,2. The early choice of these two CNS disease trials as indicators (along w/other choices we do not know about) are evidence of a good plan."
= THE BEST SCENARIO. THANKS!
Isn't "We already knew that" by Dr. M? : )
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