Biotech Values

[Whalatane]

Dew ..ESPR / MDGL etc
I'm on a PCSK9 plus Zetia ...cost thru Kaiser is around $280 a month
I'll get a lipid panel run at the end of the month and if I remember will post the results .
My LDL cholesterol without drug therapy is around 300 mg/dl. I'm hetero FH

Max dose Crestor ( the strongest Statin ) , plus Zetia gets my LDL down to 120-140mg/dl .
I want to get my LDL below 70mg/dl so we'll see if the PCSK9 / Zetia combo can do that .

The problem I see for ESPR. ( beside price competition ) is
1 ) roughly 1% of those in their trials experience elevations in ALT / AST ( Liver enzymes ) greater then 3 times normal limit
2) MDGL . MGL-3196 lowers LDL cholesterol slightly better then ESPR drug in a similar population ...28.5 % LDL reduction vs 28% LDL reduction .
While ESPR's drug significantly lower hs Crp , MGL-3196 significantly lower risk markers such as ApoB, Lp9a ) and TG's
BUT ...most of all MGL-3196 reduces Liver enzymes with more normalization of ALT

So here we have a drug MGL-3196 that lowers CV risk markers ( LDL etc ) AND improves Liver function , reduces Liver fat and to some extent , may reverse Liver fibrosis .

Seems to me a far better drug then ESPR's.

Comments , counter arguments welcome.

Believe MDGL is releasing updated Lipid data at a conference this wk . Anyone have any info on that ?

Kiwi