You make some good points but don't forget that Mundipharma, B. Braun, and NHS have all put their stamp of approval on the product. Seriously doubt they would do that if they weren't confident in the product efficacy. I would be very surprised if Actipatch can alleviate pain to the extent opioids do. But a huge difference exists...one can kill you...and one doesn't. So let's just say Actipatch is the next best thing. That'll be good enough to make it wildly successful! Go Biel$$$