Saturday, August 04, 2018 10:34:11 AM
1. Introduction: precision pharmacology in the context of precision medicine
1.1. The road to precision pharmacology: role and contribution of time and space in systems biology for research & development programs
1.1.1. Role of time
1.1.2. Role of space
2. Homeostasis and pathway-based therapy
3. Current status of blood-based biomarkers – inflammatory and metabolomic – for preclinical Alzheimer’s disease
3.1. Inflammatory biomarkers
3.2. Metabolomic biomarkers
3.3. Biomarker perspectives
3.3.1. Biomarkers as diagnostics
3.3.2. Biomarkers as guides to therapeutics
4. Cns inflammation in Alzheimer’s disease stages biomarkers and therapeutic targets
5. Anti-amyloid beta and anti-tau therapeutic strategies
6. Rethinking and optimizing the design of clinical trials from the precision medicine perspective
6.1. The right drug
6.2. The right dose
6.3. The right patient
6.4. Conduct of precision medicine trials for Alzheimer’s disease
7. How can drug discovery programs in Alzheimer’s disease accomplish a good level of translational quality to reduce the rate of failures?
7.1. Drug discovery translational for Alzheimer’s disease therapeutics
7.2. Inadequate drug discovery process
7.3. Inadequate target engagement to test the therapeutic hypothesis
7.4. Therapeutic hypothesis is changed to accommodate the compound properties
7.5. What can we do better?
8. Perspectives
Contributors to the Alzheimer precision medicine initiative – working group (APMI–WG)
I notice Abbvie is part of this consortium. I wonder if they might be a potential partner?
"The refusal of the real is the number one dogma of our time" Rene Girard
Recent AVXL News
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- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/06/2024 09:21:05 PM
- Anavex Life Sciences Reports Fiscal 2024 Third Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 08/06/2024 11:30:00 AM
- Anavex Life Sciences to Announce Fiscal 2024 Third Quarter Financial Results on Tuesday, August 6, 2024 • GlobeNewswire Inc. • 08/01/2024 11:30:00 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 07/30/2024 09:20:53 PM
- Anavex Life Sciences Announces Translational Biomarker Data for ANAVEX®2-73 (blarcamesine) in Fragile X Syndrome (Major Cause of Autism) at the 19th NFXF International Fragile X Conference • GlobeNewswire Inc. • 07/30/2024 11:30:00 AM
- Form S-3 - Registration statement under Securities Act of 1933 • Edgar (US Regulatory) • 07/29/2024 09:21:49 PM
- Results from Anavex Life Sciences Landmark Phase IIb/III Trial of Blarcamesine Presented at Alzheimer's Association Conference • GlobeNewswire Inc. • 07/28/2024 09:00:00 PM
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- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/17/2024 10:01:00 AM
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- Shareholders that lost money on Anavex Life Sciences Corporation(AVXL) Urged to Join Class Action - Contact The Gross Law Firm to Learn More • PR Newswire (US) • 05/10/2024 09:45:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/09/2024 08:35:55 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/09/2024 12:00:30 PM
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- Anavex Life Sciences Corporation Sued for Securities Law Violations - Contact The Gross Law Firm Before May 13, 2024 to Discuss Your Rights - AVXL • PR Newswire (US) • 05/03/2024 09:45:00 AM
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- May 13, 2024 Deadline: Contact The Gross Law Firm to Join Class Action Suit Against AVXL • PR Newswire (US) • 04/26/2024 09:45:00 AM
- Contact The Gross Law Firm by May 13, 2024 Deadline to Join Class Action Against Anavex Life Sciences Corporation(AVXL) • PR Newswire (US) • 04/19/2024 09:45:00 AM
- The Gross Law Firm Reminds Shareholders of a Lead Plaintiff Deadline of May 13, 2024 in Anavex Life Sciences Lawsuit - AVXL • PR Newswire (US) • 04/16/2024 09:45:00 AM
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