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Re: Lykiri post# 179608

Monday, 06/25/2018 6:33:13 PM

Monday, June 25, 2018 6:33:13 PM

Post# of 706495
The same article also includes:

Randomization was performed centrally and was stratified by clinical site and MGMT (O6-methylguanine-DNA methyltransferase) gene promoter methylation status,



https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1507-6

I get the impression that the stratification factors can impact the final randomization outcome. The goal might be a 2 to 1 ratio per clinical site, but this would never be exactly 66.7% - 33.3% (for example if a hospital has a total of 4 or 5 patients, then it will never be a 2 to 1 ratio) ... and with many, many sites this could throw of the final cumulative percentages?
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