Biotech Values

[ghmm]

Dew/Gradstudent,

Not to butt in on your good discussion but a question on MAB's. I do not have a science background and was wondering on your thoughts on the different types of MAB’s in particular Murine. I am familiar with the Nature Biotech article that is critical of the poor success ratio of Murine MAB’s (“Monoclonal antibody successes in the clinic” http://tinyurl.com/y66766) but it is my understanding that a mouse MAB would be something the body would (more easily) recognize as foreign and thus more likely to mount an attack against it which seems desirable in an indication like cancer. Not sure if that is how Zevalin/Bexarr work but it sounds logical to a non-science guy anyway.

I guess what I am getting at is do you feel one type of MAB (Human/Humanized) is better in general (could be unfair to generalize I know) or are there characteristics of Chemeric and Murine that make them suited for certain indications.

Thanks in advance!