Re: Lucentis vs Avastin
PGS is right in that the illustrations are simplified depictions of the design process. Presumably most doctors don't care how they were made, just the affects of the final product (clinical trials results, PK data.)
Both omit the humanizing/chimerizing step that involves recombinant DNA, and many other technical, albeit standard, procedures involved.
Edited to add: I don't know what the relative yields and costs are for producing the two drugs. That may be significant too.
In terms of drug optimization, sometimes that is a matter of luck, dependent on how long you test and screen and how good your screening method is.