Anavex Life Sciences Corp (AVXL)

[OFP]

Good and so some are presuming 30mg scaled down to little girls is not tolerable, on what basis?

I think you have the logic backwards there. The FDA will demand a data driven clinical trial protocol. They will incorporate the only HUMAN data they have for tolerability before giving 2-73 to HUMAN children. That HUMAN data suggests that the majority of adults with an average weight of ~76.5kg do not tolerate doses above 30mg.

If you do the conversion that F1ash gave you for mouse data you'll see that a 5mg/kg MOUSE dose converts to 31mg in a 76.5kg HUMAN. I think in a different post you used 100mg instead of the 100mg/kg used in the seizure study. I've been pointing out for a very long time the high doses needed for effect. Maybe now it's more apparent.

BTW, since the relationship is linear you can multiply from 5mg/kg equivalent 76.5kg human dose of 31mg as needed. So 10mg/kg is 62mg and 100mg/kg is 620mg. You can go back to pediatric dosing from there.