Anavex Life Sciences Corp (AVXL)

[F1ash]

Let me reiterate that I’m not an expert, just an average Joe trying to educate myself on biotech intricacies.

That being said, I believe that the 30 mg you referenced is the “mouse dose”. I believe that because the graph is labeled...

“Significant Seizure Reduction with ANAVEX2-73 in both MES and PTZ-Induced Seizure Models”

Pg. 6 http://www.anavex.com/my_uploads/Assessment-of-Anavex-2-73-in-a-MECP2-Rett-Syndrome-Mouse-Model.pdf

“This explains that two simple seizure models in mice and rats, the MES and s.c. pentylenetetrazole (PTZ) tests, which have been developed >60 years ago, are still the most widely used animal seizure models employed in the search for new AEDs. ... Anticonvulsant spectrum of AEDs in models and man. “NE” = not effective.”

https://www.sciencedirect.com/science/article/pii/S1059131111000124

I therefore believe (reminder I’m not an expert so check my work) that what you are looking at is the “mouse dose” and would need to use the conversion formula ...

HED (mg/kg) = Animal Dose (mg/kg) x [Animal Km / Human Km]

Human Km = 37

Mouse Km = 3

Rat Km = 6

EXAMPLE:

Say a STUDY conducted on MICE reports that a dosage of 5mg/kg was used; what is the HED?

By calculation, the HUMAN EQUIVALENT DOSE (HED) = 5 x [3 / 37] = 0.405 mg/kg

To get the equivalent human dose. If, if, if that is correct and we used a weight of 20 kg for the typical Rett patient, what would the HED be?