Anavex Life Sciences Corp (AVXL)

[F1ash]

Quote:
coupled with the side effects at higher doses in the Alzheimer’s trial.


Can you substantiate the above statement, or is it your conjecture?

“Dizziness was the most common adverse event (20 incidents in 15 patients), followed by headache (16 in 10 patients). Most (94%) occurred in the first week of treatment. All were mild or moderate. Headache and dizziness are considered signs that patients are approaching their maximum tolerated dose, Dr. Missling said.

The company’s task now is to find a standard minimum dose that is strong enough to get patients to at least 4 ng/mL plasma level, without inducing these side effects.


https://www.mdedge.com/clinicalneurologynews/article/152595/alzheimers-cognition/development-sigma-1-receptor-agonist?channel=180


Out of 32 patients how many were able to achieve the stated goal? If the side effects are so mild why are they hesitant to just increase the doses? Why do you believe the initial Rett application was not accepted?