Wednesday, January 03, 2018 3:49:34 PM
Vaccines are poorly accessible in developing countries
Vaccines require cold-chain storage and are often delivered by injection, which is undesirable, less safe and more expensive to administer.
Developing thermostable solid form vaccines through non-invasive routes may represent a long-term global solution to the vaccination
challenge (Amorij, 2008)
Virosomes are an efficient vaccine delivery system
Virosomes are spherical, unilamellar lipid-based carriers, intercalated with functional glycoproteins to reflect the natural virus, however the lack
of viral RNA means there is no risk of infection (Figure 1). Virosomes can be tagged with different antigens and adjuvants, meaning they can
be tailored to target different viruses, and offer increased immunogenicity over inactivated viruses.
Currently, virosomal influenza vaccines are only available in liquid form (Amorij, 2008).
Spray drying can produce dry powders for a range of dosage forms, including inhaled or nasal drug delivery.
A dry powder is formed when a liquid feed solution or suspension is atomised using a spray nozzle, and rapidly dried using hot air. However,
while the drying process is gentle due to evaporative cooling, there is still the potential to stress and inactivate vaccine components. It has
been found that subunit and live-attenuated vaccines (and other delicate molecules such as proteins) can be protected during processing b
by incorporating them in an amorphous sugar matrix, which also offers longer term stability during storage (Kanojia, 2016)
A method has been developed to produce a powder form of virosome based influenza vaccine using spray-drying.
Formulations have been optimised for oral and nasal delivery.
http://www.upperton.com/images/pdf/t10.pdf
Recent CTLT News
- Form 10-K - Annual report [Section 13 and 15(d), not S-K Item 405] • Edgar (US Regulatory) • 09/06/2024 09:23:51 PM
- Form NT 10-K - Notification of inability to timely file Form 10-K 405, 10-K, 10-KSB 405, 10-KSB, 10-KT, or 10-KT405 • Edgar (US Regulatory) • 08/30/2024 08:16:50 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/29/2024 11:47:27 AM
- Catalent, Inc. Reports Fourth Quarter and Fiscal 2024 Results • Business Wire • 08/29/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/05/2024 04:55:50 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/05/2024 04:51:05 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/05/2024 04:45:08 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/05/2024 04:39:57 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/05/2024 04:33:35 PM
- Form 144 - Report of proposed sale of securities • Edgar (US Regulatory) • 08/05/2024 03:52:06 PM
- Form 144 - Report of proposed sale of securities • Edgar (US Regulatory) • 08/02/2024 07:37:13 PM
- Form 144 - Report of proposed sale of securities • Edgar (US Regulatory) • 08/02/2024 07:34:58 PM
- Form 144 - Report of proposed sale of securities • Edgar (US Regulatory) • 08/02/2024 07:28:42 PM
- Form 144 - Report of proposed sale of securities • Edgar (US Regulatory) • 08/02/2024 07:27:37 PM
- Form 144 - Report of proposed sale of securities • Edgar (US Regulatory) • 08/02/2024 07:22:57 PM
- Form 144 - Report of proposed sale of securities • Edgar (US Regulatory) • 08/02/2024 07:13:39 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/30/2024 09:26:54 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/30/2024 09:23:13 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/30/2024 09:12:40 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/30/2024 09:04:00 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/30/2024 08:53:51 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/30/2024 08:45:41 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/30/2024 08:39:43 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/30/2024 08:30:45 PM
- Form 144 - Report of proposed sale of securities • Edgar (US Regulatory) • 07/30/2024 03:47:24 PM
VHAI - Vocodia Partners with Leading Political Super PACs to Revolutionize Fundraising Efforts • VHAI • Sep 19, 2024 11:48 AM
Dear Cashmere Group Holding Co. AKA Swifty Global Signs Binding Letter of Intent to be Acquired by Signing Day Sports • DRCR • Sep 19, 2024 10:26 AM
HealthLynked Launches Virtual Urgent Care Through Partnership with Lyric Health. • HLYK • Sep 19, 2024 8:00 AM
Element79 Gold Corp. Appoints Kevin Arias as Advisor to the Board of Directors, Strengthening Strategic Leadership • ELMGF • Sep 18, 2024 10:29 AM
Mawson Finland Limited Further Expands the Known Mineralized Zones at Rajapalot: Palokas step-out drills 7 metres @ 9.1 g/t gold & 706 ppm cobalt • MFL • Sep 17, 2024 9:02 AM
PickleJar Announces Integration With OptCulture to Deliver Holistic Fan Experiences at Venue Point of Sale • PKLE • Sep 17, 2024 8:00 AM