Anavex Life Sciences Corp (AVXL)

[F1ash]

The patient population is made up of feeble geriatrics. Some probably just died from complications associated with old age and poorer health then others.

There don't appear to be any indications of safety issues with A2-73. The dropout rate in this frail population is actually pretty low. Very encouraging for probable long term safety imho.

Here is the actual data from dropouts and the reason they dropped out.


"Completed PART A (n=30)"


Discontinued (n=2)

• Consent withdrawn
• AE: Delirium; Grade 2



"Completed PART B 6 months open- label extension (n=27)"

Discontinued (n=3)

• Consent withdrawn

• AE: Dizziness; Grade 1
AE: Confusion, disorientation,
lethargy; Grade 1



"Completed PART B 12 months open- label extension (n=25)"


Discontinued (n=2)

• Consent withdrawn
• Lost to follow up


See slide 22 which appears to indicate that the above dropouts are only for the first 54 weeks and not from the Part B ( 52 week extension of the extension). Probably very confusing to most investors imho.

http://wsw.com/webcast/jeff105/avxl/