Amarin Corp Plc (AMRN)

[HDGabor]

BB-

John Thero:

Now when the improvement results came out, we had an opportunity to revisit that, because we had done variety of research early on, and we're hearing geez, anything in double digits would be terrific. We're aiming for higher but anything in double digits would be terrific. Then we saw the improved results came out around seven and that subsequently it sort of got understood and maybe really it wasn’t a true seven, But at seven there was some enthusiasm and we started hearing from docs yes, particularly given the safety profile that Vascepa has and the price point, you can do that, high single digits might be terrific and you will get use at that level. We're aiming higher than that. The trial is designed around detecting 15% relatively risk -- relative risk reduction. There is data out there suggesting that our results could be higher than that. But in terms of the feedback, adding double digit's, potentially high single digits could be clinically meaningful, particularly given the safety and tolerability and cost profile of Vascepa.

Best,
G