Biotech Values

[DewDiligence]

More on Rasilez with Norvasc:

Speedel’s investigators appear to be using a loose definition of additive:

http://www.siliconinvestor.com/readmsg.aspx?msgid=22781979

In a meta-analysis including studies of various durations, the investigators found that Rasilez added to 5mg of Norvasc worked about as well as 10mg of Norvasc alone. I might call this incremental but I would not necessarily call it additive.

To call the combination of Rasilez and Norvasc additive, I would want to see that the combo produced a clinical benefit that was as great as the sum of the benefits of Rasilez monotherapy and Norvasc (5mg) monotherapy. So far, I have not seen any evidence that it does. Hence the comment in #msg-13100149: “Rasilez is apparently not synergistic with Norvasc (the leading calcium-channel blocker) and the clinical benefit may not even be additive.”