Ok. That makes your position and theory quite clear. The issue I see as problematic with anything where z<0 in your graph is that we saw activity favoring placebo in other trials and that would need to be taken into consideration before concluding that any activity is good activity. The length of the hold is also interesting in light of the fact that holds can and have been placed on trials where rapid enrollment near the end of a trial has occurred. This is done to allow data points to mature. To have 19 months pass for data to mature in this disease setting seems quite telling though not conclusive by any means. Best wishes.
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