NorthWest Biotherapeutics Inc (NWBO)

[maverick_1]

Thks DoingMyBest for overcoming yet another High Hurdle!

I do agree with what you have shared and just wanted to add the following as it relates to Pfizer. So since we are at the table, I will raise you two bits:

Pfizer as the kingpin of Big RX being the poster child of "Drugs Going Off Patent" Pfizer has undergone massive restructuring since some of the best selling drugs in the industry which Pfizer sells have gone off patent plus competitive developments that has required Pfizer under the leadership of Ian Reed to focus almost exclusively on near term revenues and EARNINGS: One needs only look at Lipitor, Celebrax; Viagara. AND the 2 yr journey & aborted purchase acquisition of Astra Zeneca due to US legislation on the tax inversion front which resulted recently in Pfizer's being top bidder in buying Mediivation!

Despite the above, this is happening with Pfizer's Immunotherapy endeavors:

1 Two years ago PFE/MRK Collaboration:

"This collaboration between Pfizer and Merck is just one example of the willingness of sponsors to work together in an effort to accelerate progress against some of the most difficult-to-treat cancers," said Dr. Mace Rothenberg, senior vice president of Clinical Development and Medical Affairs and chief medical officer for Pfizer Oncology. "Understanding the effects of combining one drug, XALKORI, which inhibits an abnormally activated enzyme in patients with ALK-positive metastatic lung cancer, with the investigational drug, pembrolizumab, which harnesses the body's immune system to fight cancer, is vital if we are to continue to advance the care of lung cancer patients."

http://www.fiercepharma.com/pharma/pfizer-and-merck-to-collaborate-on-study-evaluating-novel-anti-cancer-combination-regimen

2. Over two years ago I recall and posted on Pfizer doing the following for their involvement in the CAR T space with Cellectis (gene editing)::
http://www.pfizer.com/news/press-release/press-release-detail/pfizer_and_cellectis_enter_into_global_strategic_cancer_immunotherapy_collaboration
AND more recently:
http://www.fiercebiotech.com/r-d/pfizer-looks-to-cut-line-car-t-off-shelf-approach

3. Pfizer did get FDA approval 2/15 for their immuno oncology breast cancer ibrance:
http://www.fiercepharma.com/marketing/pfizer-keeps-pushing-on-early-hit-ibrance-as-novartis-lilly-rivals-near-market

4. The latest update from Pfzier's Head of Cancer May 2016:
http://www.fiercepharma.com/pharma/pfizer-cancer-chief-touts-up-and-coming-portfolio-sees-pricing-advantage-immunotherapies

Lastly, it is indeed appalling why given Larry Smith's life long exposure to Big RX's that he provides what I consider little to no commentary given the vitalness of success with NWBO's two year endeavor of NWBO's DIRECT Combo Partnering program! My sense here, added to what I expressed yesterday and the day before is Larry Smith is decidedly conservative by nature and it is personally reflective in his own admission: Given my recall abilities Larry Smith did state 90+% of his net worth is tied up in real estate (that was stated 2 yrs ago). Just hope it is not in New Jersey (likely since his commute was to midtown Manhattan). And the reason which I had to uncover for another party what they SHOULD HAVE KNOWN: those having lived/owned real estate in New Jersey: The Tri State area made lots of poor financial home equity decisions in the mid 2000's by taking equity out of their properties; followed by the Great Worldwide US Induced Recession; massive Big Rx's LAYOFFS AND state foreclosure regulations which average a 2-3 yr delay unlike that of ie CA; AZ; NV has resulted large inventory overhang; significantly lagging that of the US! Witness the following on New Jersey which had the dubious distinction in 2015 as having the highest amount of home foreclosures:

[New Jersey, Florida, Maryland post top state foreclosure rates in 2015

States with the highest foreclosure rates in 2015 were New Jersey (1.91 percent of housing units with a foreclosure filing); Florida (1.77 percent); Maryland (1.60 percent); Nevada (1.40 percent); and Illinois (1.26 percent)

:http://www.realtytrac.com/news/foreclosure-trends/realtytrac-2015-year-end-u-s-foreclosure-market-report/ buttressed sadly by the devastation of Hurricane Sandy that the latest: http://www.bankrate.com/finance/real-estate/state-foreclosures-new-jersey/

With the above, it should complete (with the previously noted exception of GSK) what I began 2 weeks with the unanimous viewpoint of KEY practitioners about PD-1/PD-L1 Combo's.

With last week's NWBO announcements of NASD/Cognate holdings agreement and likely the last small equity raise, NWBO is embarking IMHO upon a NEW Chapter in it's second revival from the Ashes to the expected Phoenix.