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shears

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shears

Re: Democritus_of_Abdera post# 76

Sunday, 07/23/2006 11:23:48 AM

Sunday, July 23, 2006 11:23:48 AM

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OK, so where does Fab-anti-VEGF need to be concentrated? In the retinal tissue or inside the blood vessels in the retina? How much VEGF is actually floating around inside the vitreous to theoretically gum up the device? Does this vitreous VEGF need to be overwhelmed by an injection of lucentis so the unbound can get in or around the retinal vessels?

If VEGF is not a normal constituent of the vitreous or present in only trivial amounts then it seems to me there is an advantage to prolonged release of lucentis since the half life after ocular injections is only 3 days or so.
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