NorthWest Biotherapeutics Inc (NWBO)

[highwayman4life]

For now their Phase II is only being developed as a "mono-therapy" and not as a "combination therapy"

Seems to me like they are most definitely interested in Direct being a combo therapy.

NWBO's Takeaways from ASCO 2015:

We think data from the ASCO presentation are very encouraging. We are especially impressed with these positive results across diverse types of cancers in late stage patients with multiple inoperable tumors who have exhausted other treatment options, and with quite a conservative DCVax-Direct treatment regimen.

We further believe the positive data from the Phase I trial will accelerate the initiation of the planned Phase II trial of DCVax-Direct, which, in addition to the Phase III trial of DCVax-L for brain cancer, will serve as another key value driver the company.

The findings from the Phase I trial also open the door for potential combination therapy of DCVax-Direct with checkpoint inhibitors.

Thought you might find this interesting to read?

http://patents.com/us-20150273033.html

Abstract

The present disclosure arises at least in part from the seminal recognition that a combination treatment regimen including one or more cycles and/or doses of a checkpoint inhibitor and a therapeutic, either sequentially, in either order, or substantially simultaneously, can be more effective in treating cancer in some subjects and/or can initiate, enable, increase, enhance or prolong the activity and/or number of immune cells, or a medically beneficial response by a tumor.