Innovation Pharmaceuticals Inc (IPIX)

[ROMAD Diver]

Higher dosage doesn't necessarily mean higher P21 levels. I will use caffeine as an example..

Caffeine moves freely through most cells in the body. It has been shown to offer huge benefits to alertness, physical endurance, pain reduction, and offers an ergogenic effect in the 3-6mg per kg of body weight range. However, at 9mg per kg of body weight and above it overstimulates the cells, and causes the opposite effects: lethargy, reduced physical endurance, etc...

Kevetrin will have a "sweet spot" that it performs best at. As stated on this board previously, the investigators probably already found it, and now want to finish up this trial so they can start the next one. I would imagine the reason for the large number of additional patients was to ensure they could difinitively capture and understand some specific data points and cellular processes before ending the trial. IMO...

I won't doubt it if major cellular breakthroughs come out of this trial because of the better understanding of the p52/p21 relationship.