P21 expressions have been proven to be dose dependent. Higher dosage means higher p21 levels. Higher p21 levels mean more p53s are reactivated. We all know what healthy p53s can do.
The thymoma patient already has a 6% tumor reduction with 350/450 mg/m2 once per week. I find it hard to believe that his tumor will progress with 750 mg/m2.
The five ovarian patients with progressive disease are mostly likely from the lower cohorts. I think our focus should be on the four patients with stable disease from the higher cohorts.
Uh, no it's not. It could very easily remain stable or it could progress. Happens all the time in clinical trials.