It’s all about the cost, about the cost. Right now the overall cost per case is lower with Vanco vs. Dapto. Overall costs include drug costs, I/P, O/P, pick lines, monitoring, complications, drug interactions, resistance, readmission, etc. Dapto has a somewhat better treatment regimen, dosing once per day vs. possibly twice for Vanco, and 7 – 14 days vs. 14 days. Any savings in non-drug costs do not outweigh the drug cost of Dapto. Thus, Dapto is only used when Vanco cannot be used. However, when Dapto goes generic, it will displace Vanco as the drug of choice, IMO(beating out Sivextro and Dalvance). So the question is…how will Bril compete with a generic Dapto? I believe Bril will be the drug of choice over a generic Dapto because the reasons you post will generate non-drug cost savings that will exceed the cost of Bril. I am waiting for the bottom line data to post further detail on this view.